Figure 4.

Knockdown of Wrap53 suppresses nude mouse colorectal cancer cell xenograft formation and growth in vivo. (A) Stable Wrap53-B knocked down HCT116 cells or negative control cells were subcutaneously injected into the right flank region of nude mice (n=10 each of group). Twenty-one days later, the mice were killed and photographed. (B) Tumor xenografts. Tumor xenografts were resected and weighted. (C) The weight of shWrap53-B tumor xenografts was significantly less than negative control xenografts (*** P<0.001; t test). (D) Tumor xenograft growth curve. The volume of shWrap53-B tumor xenografts was significantly lower than that of negative control xenografts (** P<0.01; t test at day 21).