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. 2018 Sep 4;12:288. doi: 10.3389/fncel.2018.00288

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Copyright © 2018 Shen, Gu, Liu, Xu, Qian, Zhang, Zhou, Guan, Sun, Wang and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of 2-h ischemia on blood brain barrier (BBB) damage and matrix metalloproteinase-2 (MMP-2)/9 activity. (A) After in situ zymography procedure, ischemic region (I) with dextran leakage (bottom left panel) and its corresponding tissue (upper left panel) in the non-ischemic hemisphere (NI) were chosen for microscopic observation. Fluorescent micrographs showed increased gelatinolytic activity of MMP-2/9 along ischemic microvessels (bright green fluorescence), where dextran leakage concurrently occurred. Spotted distribution of increased gelatinolytic activity was also seen in the leaky area. No dextran leakage and weak gelatinolytic activity were seen in the corresponding region of the NI hemisphere. (B) Quantitative data of MMP-2/9 activity (n = 3). **P < 0.01 compared to MMP2/9 activity in NI hemisphere.