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. 2018 Sep 4;12:288. doi: 10.3389/fncel.2018.00288

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Copyright © 2018 Shen, Gu, Liu, Xu, Qian, Zhang, Zhou, Guan, Sun, Wang and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of 3-(5’-Hydroxymethyl-2’-furyl)-1-benzyl indazole (YC-1) treatment on 2-h ischemia-induced BBB damage and MMP-2 induction. Rats received YC-1 at 24 h and 30 min before the onset of ischemia. Evan’s blue (EB) leakage (red) was seen in the ischemic region of interest 2 (ROI 2) after 2-h ischemia and in situ zymmography showed increased MMP-2 activity in the brain area where EB leakage occurred. Pretreatment with YC-1 significantly prevented MMP-2 induction as well as EB leakage. n = 3/group.