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Effect of hypoxia-inducible factor-1 alpha (HIF-1α) inhibition on colocalizaion of vascular endothelial growth factor (VEGF) with EB leakage. Representative fluorescent micrographs of EB leakage (red) and VEGF expression in non-ischemic (NI) and ischemic site (I). Two-hour MCAO induced significant EB leakage (BBB damage) in ROI 2 of ischemic site and inhibition of HIF-1α with YC-1 significantly decreased EB leakage. n = 4.
