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. 2018 Sep 4;12:288. doi: 10.3389/fncel.2018.00288

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Copyright © 2018 Shen, Gu, Liu, Xu, Qian, Zhang, Zhou, Guan, Sun, Wang and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of YC-1 on 2-h ischemia-induced VEGF expression in neurons and astrocytes. The cellular distribution of VEGF was analyzed by immunostaining with NeuN (marker of neurons) or GFAP (marker of astrocytes) after 2-h MCAO. Double immunostain of VEGF (green) and NeuN (red) showed a good colocalization of VEGF and neurons and YC-1 treatment significantly decreased the proportion of VEGF-positive neurons (A). Double immunostain of VEGF (green) and GFAP (red) showed no co-localization of VEGF and astrocytes (B). After quantification, two-way ANNOVA showed an increased proportion of VEGF positive neurons and YC-1 significantly decreased this upregulation (C,D). n = 3/group. Scale bar = 50 μm. n = 3/group. *P < 0.05 compared to the NeuN+/VEGF+ cells in the NI hemisphere. ^##P < 0.01 compared to NeuN+/VEGF+ cells in I hemisphere of Vehicle group.