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Synaptically coupled (i.e. communicating) neurons are under constant surveillance by glial cells, including microglia. If a neuronal synapse becomes “tagged” with complement protein C3, microglia recognize the tag with their C3 receptor (CR3/CD11b). This signal tells the microglia to engulf, or phagocytosis, and degrade the synapse. After microglial synaptic pruning, the eliminated synapse changes the way neurons communicate. Adapted from Lacagnina et al., 20173.
