Fig 2.

Histology of select patient tumors; original magnification x100 unless otherwise specified. (A) Patient 2 had an adenocarcinoma with solid growth pattern, diffuse neuroendocrine differentiation, and signet ring cells; inset shows high magnification (x400). (B) Patient 1 had poorly differentiated adenocarcinoma with solid and single-cell growth patterns. (C) Patient 4 had mucinous adenocarcinoma, and patient 6 had similar histology (data not shown). (D) Patient 8 had squamous cell carcinoma. (E) Patient 11 had neuroendocrine carcinoma with well-differentiated morphology and increased mitotic activity (left); high magnification (x400) shown in middle.