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. Author manuscript; available in PMC: 2019 May 3.
Published in final edited form as: Cell. 2018 Apr 19;173(4):879–893.e13. doi: 10.1016/j.cell.2018.03.041

Figure 1 – Overview of Treatment Schedule and Experimental Design.

Figure 1 –

(A) Timeline of chemotherapy treatment schedule and sample acquisition. Core biopsies were obtained prior to NAC at 0 cycles and mid-treatment, after two cycles of NAC (docetaxel and epirubicin). The surgical sample was obtained after four additional cycles of NAC in combination with bevacizumab. (B) For each longitudinal time-point sample, three experimental procedures were performed, including bulk exome sequencing, single-cell copy number profiling and 3’ single-nucleus RNA sequencing using a nanogrid platform (methods).