Figure 1.

The predicted prevalence of significant depressive symptoms and cognitive impairment at baseline as a function of baseline biological and chronological age. (a) Significant depressive symptoms (CES-D ≥ 10). (b) Significant cognitive impairment (3MS ≤ 78). Note: Depicted is the predicted prevalence of experiencing significant depressive symptoms (Figure 1a; CES-D ≥ 10) and significant cognitive impairment (Figure 1b; 3MS ≤ 78) at baseline with the 95% confidence intervals plotted against BA and CA. The regression line for CA was extended beyond the baseline age range (68–80 years; reflected as a dashed line) for ease of comparison between BA and CA. BA = Biological age; CA = Chronological age; CES-D = Center for Epidemiologic Studies Depression scale.