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. 2018 Sep 7;11(6):1364–1369. doi: 10.1016/j.tranon.2018.08.010

Figure 2.

Figure 2

Gene alterations of ARID1A in patient #SR01. (A) A schematic map indicating multiple missense mutations identified in exon20 of the ARID1A gene in patient #SR01. Asterisks (*) indicate mutations present in the COSMIC database. (B) An integrative genomic viewer (IGV) visualization of the sequencing reads of the ARID1A-MTOR fusion gene (top panel). The gray portion indicates sequencing reads of MTOR intron 31, while the colored portion represents the sequencing reads of ARID1A exon 20. The schematic map (bottom panel) shows the structure of the ARID1A-MTOR fusion locus. Exons 1-20 of ARID1A (light green) were fused to intron 31 of MTOR (gray). Blue and red triangles indicate the broken positions of two genes. (C) Mutation allele frequency changes for genes before and after TKI treatment. Pre, pretreatment; Post, posttreatment.