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Fold-change in mRNA expression of SLC7A11 (A), TRIM16 (B), SRXN1 (C), or TXNRD1 (D) in a panel of nine breast cell lines. Cells were treated with 50 μM APR-246 or DMSO for 12 hours. Data were analyzed using paired t test. All experiments were carried out in triplicate. Values are means ± SEM, *P > .01, **P > .001, ***P > .0001; p53-mut, p53 mutated; P53-WT; p53 wild-type.
