Table 3.
Odds Ratios (95% CIs) for OHSUD Associated With Various Lipid Measurements by Univariate and Multivariate Analysesa,b
| Variable | Model 1c | Model 2 | Model 3 |
|---|---|---|---|
| TC level (highest vs lowest quartile) | 0.4 (0.25-0.65) | 0.43 (0.25-0.74) | 0.45 (0.22-0.95) |
| TG level (highest vs lowest quartile) | 1.00 (1.00-1.00) | 1.00 (1-1.00) | 0.73 (0.34-1.59) |
| HDL-C level (highest vs lowest quartile) | 0.43 (0.27-0.70) | 0.64 (0.37-1.13) | 0.77 (0.37-1.62) |
| LDL-C (highest vs lowest quartile) | 0.30 (0.18-0.50) | 0.32 (0.18-0.56) | 0.36 (0.17-0.77) |
| Non–HDL-C (highest vs lowest quartile) | 0.46 (0.28-0.73) | 0.45 (0.27-0.75) | 0.44 (0.21-0.93) |
| TG/HDL-C ratio (per unit increase) | 1.10 (1.05-1.15) | 1.08 (1.03-1.12) | 1.05 (1.01-1.10) |
| TC/HDL-C ratio (per unit increase) | 1.12 (0.99-1.26) | 1.04 (0.90-1.19) | 1.01 (0.83-1.23) |
| LDL-C/HDL-C ratio (per unit increase) | 0.94 (0.78-1.13) | 0.88 (0.72-1.07) | 0.85 (0.65-1.12) |
HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; OHSUD = out-of-hospital sudden unexpected death; NHANES = National Health and Nutrition Examination Survey; TC = total cholesterol; TG = triglyceride.
Local controls are the reference group.
Model 1: unadjusted; model 2: adjusted for age and sex; model 3: adjusted for age, sex, body mass index, diabetes mellitus, and interaction between respective lipid measure and lipid-lowering medication use. For the TG/HDL-C ratio, model 3 adjusts for age, sex, body mass index, and diabetes mellitus. For the LDL-C level and LDL-C/HDL-C ratio, model 3 additionally adjusts for TG level (as continuous variable).