Table 1.

Antiviral activity of elbasvir in HCV replicons of genotypes 1–6

Genotype (Gt) of HCV replicona	EC50 (nM)	EC50 (nM)
Gt 1a_H77_NC004102	0.004±0.002	0.006±0.002
Gt 1b_con1_AJ238799	0.003±0.001	0.006±0.004
Gt 2a_JFH1_AB047639	0.003±0.001	0.019±0.01
Gt 2b_AB030907/JFH1b	3.4±2.6	11±4.8
Gt 3a_S52_GU814263	0.14±0.09	0.49±0.19
Gt 4a_ED43_GU814265	0.0003±0.0001	0.0005±0.0001
Gt 5a_SA13_AF064490/JFH1b	0.001±0.001	0.002±0.002
Gt 6_DQ278892/JFH1b	0.009±0.006	0.017±0.009

Notes:

^aNames and numbers are strain designations and GenBank accession numbers;

^bJFH1-based chimeric replicon harboring NS5A sequences of Gt 2b, 5a, and 6 were used. Values are mean ± SD (n≥3). Adapted with permission from Lahser FC, Bystol K, Curry S, et al. The combination of grazoprevir, a hepatitis C virus (HCV) NS3/4A protease inhibitor, and elbasvir, an HCV NS5A inhibitor, demonstrates a high genetic barrier to resistance in HCV genotype 1a replicons. Antimicrob Agents Chemother. 2016;60(5):2954–2964.11

Abbreviations: EC, effective concentration; HCV, hepatitis C virus.