Table 3.

Inhibitory effects of elbasvir against NS5A-variant replicons

HCV replicon	Fold shift relative to WTa
1a H77 (WT)	1
1a M28T	15
1a M28V	1
1a M28A	61
1a Q30D	925
1a Q30H	6
1a Q30E	56
1a Q30R	16
1a L31M	10
1a L31F	96
1a L31V	61
1a H58D	6
1a Y93H	220
1a Y93N	929
1a Y93C	11
1b con1 (WT)	1
1b L28M	2
1b L31M	1
1b L31F	15
1b L31V	4
1b Y93H	17
1b V121I	0.2
4a ED43 (WT)b	1
4a L30Fb	15
4a L30Pb	1
4a L30Sb	4
4a M31Vb	2.5
4a N69Kb	1.5
Y93Hb	7.5

Notes:

^aThe fold shift calculated using EC₅₀ concentration;

^bchimeric replicons bearing resistant-associated substitutions generated in a Gt 2a (JFH1) backbone. Modified from Lahser et al,11 Asante-Appiah et al,15 and Liu et al.16

Abbreviations: EC, effective concentration; HCV, hepatitis C virus; Gt, genotype; WT, wild type.