Table 3.
Pooled rates of main clinical outcomes
| Study (n) | Patients (n) | P-value, He | I2 (%) | Egger’s test, P-value | Events (95% CI) | |
|---|---|---|---|---|---|---|
| RR | ||||||
| Overall | 8 | 521 | <0.001 | 75.2 | 0.49 | 73.1 (63.6–80.9) |
| High dose | 6 | 313 | 0.035 | 58.2 | 0.324 | 82.2 (74.4–88.1) |
| Low dose | 6 | 161 | 0.362 | 8.5 | 0.551 | 51.1 (40.3–61.7) |
| High dose vs low dose P=0.001 | ||||||
| OS | ||||||
| 1-year OS | 5 | 331 | 0.129 | 43.9 | 0.464 | 41.0 (32.9–49.6) |
| 2-year OS | 5 | 373 | 0.566 | 0 | 0.408 | 19.9 (16.1–24.3) |
| Median OS in months 8 (5.8–19) |
Abbreviations: CI, confidence interval; OS, overall survival; RR, response rate.