Figure 2.

Deficits in high-frequency activity in cortex following trkb deletion from PV+ interneurons. (A) LFP Population average power spectra of spontaneous LFP activity in primary visual cortex of control (black) and mutant (blue) animals. (B) Mutants showed a significant deficit in gamma band (30–50 Hz) during both spontaneous and sensory-evoked activity. (C) Elevated spontaneous, but not visually evoked, firing rates in regular spiking (RS), putative excitatory neurons in visual cortex of mutants. (D) TrkB cKO mutants showed no significant change in striatal firing rates.