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. 2018 Aug 28;9(67):32841–32854. doi: 10.18632/oncotarget.26003

Figure 4. PAX5A and PAX5B drive a comparable transcriptomic early B cell program.

Figure 4

(A–C) Volcano plots presenting the fold change in log2 on x axis and the log10 p-value of the false discovery rate permutation analysis on y axis of the transcriptome comparing eGFP expressing vector (MIE) to PAX5A (A), MIE to PAX5B (B) and PAX5A to PAX5B (C) showing the similar effect of PAX5A and PAX5B on early B cell differentiation restoration. For C, gene with a difference of expression >2 fold between PAX5A and PAX5B are listed. (D) Scatter graph with gene expression fold changes between PAX5A and MIE on x-axis and PAX5B and MIE on y-axis. The regression line shows the relationship between PAX5A and PAX5B impact on target gene expression. As example, Cd19 up-regulated gene and Gp49a and Cd7 down-regulated genes are indicated.