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. 2018 Aug 28;9(67):32822–32840. doi: 10.18632/oncotarget.25999

Figure 2. Impact of DAC, AZA and vitamin C on genomic 5-mdC/dC levels in human colon cancer cells.

Figure 2

HCT116 cells were exposed to increasing concentrations of vitamin C (A) for 72h. In addition, DAC (B) and AZA (C), alone (striped bars) or in combination with 10 μM vitamin C (grey bars) and 50 μM vitamin C (black bars), were exposed to the HCT116 colon cancer cells for 72 h. The genomic levels of 5-mdC/dC were then assessed by LC-MS/MS. Statistical significance was calculated using 2-way ANOVA and Tukey post-test (****p < 0.001 – significant results; error bars = SD; n=3).