Table 1.

Identification of in vitro utrophin mRNA inducers from Connectivity Map

No.	Drug	UTRN fold‐expression (Cmap data)	p38 MAPK effect	References for p38 effect
1	Anisomycin	1.50	+	Liu et al. (2014); Farooq et al. (2009); Xiong et al. (2006)
2	Emetine	1.47	+	Kim et al. (2015); Islam et al. (2006)
3	Cycloheximide	1.44	+	Oksvold et al. (2012); Itani et al. (2003)
4	Chlorzoxazone	1.40	?
5	Chelidonine	1.38	?
6	Loxapine	1.38	?
7	Piperacetazine	1.38	?
8	Tacrine	1.36	–	Li et al. (2005)
9	Alexidine	1.35	–	Zhu et al. (2015)
10	Lobeline	1.33	?

Top 10 hits from the in silico screen. Relative expression of utrophin is derived from the three cancer cell lines, MCF7, HeLa, and PC3, treated for 6 hours with 10 μM drug. (+) upregulation, (–) downregulation, (?) not indicated in the literature.31, 32, 33, 34, 44, 45, 46, 47, 48, 49