Figure 4.

(a) Area under the curve (AUC)_0–24h of testosterone and its primary and secondary metabolites in individual subjects after single oral dose of testosterone at T200 and T800 with and without dutasteride co‐administration (n = 7). Dots indicate individual data, horizontal line represents mean and error bars indicate SE. (b) Relative quantitative representation of mean AUC_0–24h of testosterone, and its primary and secondary metabolites after single oral dose at T200 and T800 with and without dutasteride co‐administration (n = 7). Metabolic scheme and enzymes involved in testosterone metabolism are shown as reported in ref. 15. Size of the circle and number (nx) indicate relative mean AUC_0–24h of individual metabolites as compared with testosterone in respective studies. Glucuronides are the major circulating metabolites of testosterone. Data were analyzed using Paired t test, *P value < 0.05, **P value < 0.01, ***P value < 0.001. AED, androstenedione; AG, androsterone glucuronide; DHT, dihydrotestosterone; Etio, etiocholanolone; EtioG, etiocholanolone glucuronide; T, testosterone; TG, testosterone glucuronide.