Table 1.
Baseline characteristics
| NLR < 2.5 (n = 789) n (%) |
NLR ≥ 2.5 (n = 562) n (%) |
p Value | |
|---|---|---|---|
| Mean age (95% CI)a | 59 (58 to 60) | 63 (61 to 64) | <0.001 |
| Sex (%) | |||
| Male | 368 (47) | 310 (55) | 0.002 |
| Female | 421 (53) | 252 (45) | |
| Median Breslow thickness: mm (IQR) | 1.9 (1.2 to 3.1; 0.3 to 24) | 1.9 (1.2 to 3; 0.5 to 15) | 0.9 |
| Median mitoses: mm−2 (IQR) | 3 (1 to 7) | 3 (2 to 8) | 0.6 |
| Median maximum diameter: mm (IQR) | 10 (7 to 14) | 11 (7 to 15) | 0.2 |
| Ulceration | 196 (27) | 127 (24) | 0.3 |
| Angiolymphatic invasion | 21 (6) | 12 (5) | 0.4 |
| Perineural invasion | 14 (4) | 10 (4) | 0.9 |
| Regression | 40 (12) | 53 (21) | 0.003 |
| Microsatellites | 15 (4) | 14 (6) | 0.6 |
| Tumor-infiltrating lymphocytes | |||
| Absent | 53 (16) | 39 (16) | 0.2 |
| Non-brisk | 222 (69) | 152 (63) | |
| Brisk | 48 (15) | 50 (21) | |
| Vertical growth phase | 297 (97) | 232 (99) | 0.2 |
| Pathologic subtype | |||
| Nodular | 87 (11) | 57 (10) | N/A |
| Superficial spreading | 230 (29) | 179 (32) | |
| Acral | 12 (2) | 10 (2) | |
| Other | 460 (58) | 316 (56) | |
| Sentinel lymph node(s) containing metastatic melanoma | 148 (19) | 126 (22) | 0.1 |
| Extracapsular spread | 12 (16) | 4 (7) | 0.08 |
| AJCC Stage after sentinel lymph node biopsy | |||
| I | 518 (66) | 372 (66) | 0.04 |
| II | 121 (15) | 63 (11) | |
| III | 148 (18) | 126 (22) |
NLR neutrophil–lymphocyte ratio; CI confidence interval; IQR interquartile ratio; N/A not applicable
aGeometric mean