Table 3.
Estimated formulas for the anticancer drug concentration in the plasma
| Anticancer drugs | Carrier solutions | Estimated formulas of the graph for the plasma drug concentrations (MMC: Fig. 2a, oxaliplatin: Fig. 2c) | Estimated concentration gradient (SE) | p value† |
|---|---|---|---|---|
| Mitomycin-C | Dianeal® | Cplasma = 3.05 · time + 30.99 | 3.05 (0.21) | < 0.0001 |
| Lipid solution | Cplasma = 0.74 · time + 27.80 | 0.74 (0.23) | ||
| Oxaliplatin | Dianeal® | Cplasma = 59.15 · time − 126.21 | 59.15 (7.52) |
< 0.0001 (Dianeal vs. 5DW, p < 0.001; Dianeal vs. lipid, p = 0.3957; 5DW vs. lipid, p < 0.001) |
| 5% dextrose solution | Cplasma = 113.21 · time − 57.74 | 113.21 (7.35) | ||
| Lipid solution | Cplasma = 43.05 · time + 14.56 | 43.05 (7.35) |
Estimated formulas was calculated by random intercept model
Bold values are statistically significant (p < 0.05)
Cplasma, concentration of plasma; SE, standard error; 5DW, 5% dextrose
†Calculated by linear mixed model