Table 6.
Example for the comparison of two competitive products (Product A and Product B) in a multi-criteria decision analysis based on the Evidence Framework for Off-Patent Pharmaceutical Review criteria [48]
| Criteria (requirements) | Importance factora | Weighta W (%) | Product A | Product B | |||
|---|---|---|---|---|---|---|---|
| Rating C (0–4)b | Score (W × C) | Rating C (0–4)b | Score (W × C) | ||||
| Product | Equivalence with reference | 10 | 12 | ||||
| Pharmaceutical technology | 2 | 2 | |||||
| Manufacturer | Quality assurance | 10 | 12 | ||||
| Supply track record | 8 | 9 | |||||
| Local investment | 5 | 6 | |||||
| Service | Pharmacovigilance | 8 | 9 | ||||
| Product-related value-added services | 2 | 2 | |||||
| Value assessment | Pharmaceutical acquisition cost | 35 | 41 | ||||
| Real-world patient outcomes and cost | 5 | 6 | |||||
| 85 | 100 | Total score A | Total score B | ||||
aThe weighting is computed from the importance factor, which is adapted according to the local requirements, specifications, and priorities
bThe rating scale used here is from 0 (bad performance vs. requirement) to 4 (perfect performance vs. requirement). Each rating must be clearly defined before the evaluation to avoid inter-rater variability