As the efficacy of triple-therapy antiretroviral regimens remains consistently high, patient well-being (e.g., patient-reported outcomes [PROs]) has become an important differentiator between regimens.

We evaluated PROs in two studies comparing co-formulated bictegravir, emtricitabine, and tenofovir alafenamide (B/F/TAF) with co-formulated abacavir, dolutegravir, and lamivudine (ABC/DTG/3TC), where treatment differences were noted if prevalence was statistically significantly different at two or more time points in the adjusted logistic regression model or at one time point in the adjusted logistic regression model and in the longitudinal model.

Among treatment-naïve participants, initiating B/F/TAF was associated with lower prevalence of fatigue/loss of energy, dizzy/lightheadedness, nausea/vomiting, difficulty sleeping, and loss of appetite compared with ABC/DTG/3TC.

For virologically suppressed participants, switching to B/F/TAF was associated with lower prevalence of dizzy/lightheadedness, nausea/vomiting, sad/down/depressed, nervous/anxious, difficulty sleeping, and loss of appetite compared with remaining on ABC/DTG/3TC.

In both patient populations, no symptom had a greater prevalence with B/F/TAF compared with ABC/DTG/3TC.