Table 3.

Distribution of TREO, S,S-EBDM, and busulfan into the liver, lungs, brain, and bone marrow

Tissue	Tissue/plasma AUC ratio in rats (estimated daily tissue AUC in HSCT patients [μM · h])
	TREOa	S,S-EBDMa	Busulfan
Liver	0.96–0.97 (3072–7470)	Unquantifiable	1.27b (76–127)
Lungs	0.82–0.83 (2624–7470)	0.46–0.53 (7.4–48)	1.05b (63–105)
Brain	0.10–0.11 (320–990)	0.34–0.36 (5.4–32)	0.75c (45–75)
Bone marrow	0.77–0.88 (2463–7920)	0.71–0.79 (11–71)	0.83b (50–83)

AUC area under the curve from time zero to infinity, TREO treosulfan, S,S-EBDM (2S,3S)-1,2-epoxy-3,4-butanediol 4-methanesulfonate

Data in the table are taken from Romański et al. [19]^a, Hassan et al. [54]^b, and Hassan et al. [55]^c