Fig. 4.

Metabolic engineering of the glycolysis pathway in E. coli for precursor support of the MEP and MVA pathways. pgi, phosphoglucose isomerase; pgl, 6-phosphogluconolactonase; adhE, aldehyde-alcohol dehydrogenase; dld, d-lactate dehydrogenase; eda, KDGP-aldolase; edd, 6-phosphogluconate dehydrase; ackA, acetate kinase; pkl, phosphoketolase; pta, phosphotransacetylase; pps, phosphoenolpyruvate (PEP) synthase; ppc, PEP carboxylase; pck, PEP carboxykinase; atoA, acetoacetyl-CoA transferase; pyk, pyruvate kinases; aceE, pyruvate dehydrogenase; ldhA, lactate dehydrogenase; poxB, pyruvate oxidase; pta, phosphate acetyltransferase; atoD, acetoacetyl-CoA transferase