Table 1.

Classification of drug–drug interactions in Sweden, their clinical relevance and level of documentation [18]

Clinical relevance

A: Clinically insignificant DDIs.

B: Clinical relevance is unknown and/or varies.

C: Clinically relevant DDIs that can be handled with individual dose adjustment, for example.

D: Clinically relevant DDIs that should be avoided.

Level of documentation

0: Data from studies including other drug substances with similar properties.

1: Data from incomplete case reports and/or in vitro studies.

2: Data from well-documented case reports.

3: Data from studies on healthy individuals and/or pilot studies on patients.

4: Data from controlled studies on relevant study population.

DDIs drug–drug interactions