Table 3.
Descriptive statistics of study population and comparison between people with and without clinically relevant DDIs
| Characteristics of study sample | Total | DDI(s) | No DDI | Simple OR (95% CI) | Multiple OR (95% CI) |
|---|---|---|---|---|---|
| Cases, n | 458 | 198 | 260 | ||
| Sex, n (%) | |||||
| Female | 286 (62.4) | 121 (61.1) | 165 (63.5) | 0.905 (0.618–1.325) | 0.853 (0.558–1.303) |
| Male | 172 (37.6) | 77 (38.9) | 95 (36.5) | Ref. | |
| Age (years), mean ± SD, (range) | 83.2 ± 6.6 (65–99) | 83.2 ± 6.3 | 83.3 ± 6.8 | 0.998 (0.970–1.026) | 1.008 (0.977–1.040) |
| Number of medications at admission, mean ± SD, (range) | 7.7 ± 3.5 (0–20) | 9.4 ± 3.3 | 6.5 ± 3.2 | 1.311 (1.227–1.402) | 1.312 (1.227–1.403) |
| MMSEa (0–30), mean ± SD, (range) | 19.8 ± 4.7 (7–29) | 19.5 ± 4.7 | 20.0 ± 4.7 | 0.979 (0.916–1.047) | – |
| Type of accommodation, n (%) | |||||
| Nursing home | 151 (33.0) | 62 (31.3) | 89 (34.2) | 0.876 (0.590–1.300) | – |
| Living at home | 307 (67.0) | 136 (68.7) | 171 (65.8) | Ref. | |
| Geographic location, n (%) | |||||
| Skellefteå | 120 (26.2) | 45 (22.7) | 75 (28.8) | 0.725 (0.473–1.112) | – |
| Umeå | 338 (73.8) | 153 (77.3) | 185 (71.2) | Ref. | |
CI confidence interval, DDI(s) drug–drug interaction(s), MMSE Mini-Mental State Examination, OR odds ratio, Ref reference category, SD standard deviation
The multiple analysis includes sex, age and significant variables from the simple model (number of medications at admission)
an = 162 because the test was not performed on every patient