Table 1.

Parameters for binding of 1 to ntd-HSP90 derived from the titrations with TITAN software, for the WT and three mutants

	KD (µM)	kOFF (s−1)
WT	160–220	1400–1800
50C/54C	195–238	1500–2300
101C/105C	140–171	1075–1300
149C/187C	41–45	1300–1900