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. 2018 Jul 4;41(9):zsy125. doi: 10.1093/sleep/zsy125

Table 3.

Mediation by depression or anxiety of the association between sleep difficulties in 2011 and incident pain in 2013

Odds ratio (bootstrapped 95% CI) Percentage of sleep association mediateda
Total sleep association Direct sleep association Indirect sleep association through mediator
Mediator: Depression
 >30 minutes to fall asleep
  Unadjustedb 1.35 (1.12, 1.62) 1.34 (1.11, 1.60) 1.01 (1.00, 1.04) 0%
  Adjustedc 1.25 (1.03, 1.51) 1.24 (1.02, 1.51) 1.00 (0.99, 1.51) 0%
 Difficulty falling back to sleep
  Unadjustedb 1.33 (1.10, 1.60) 1.33 (1.10, 1.60) 1.01 (1.00, 1.03) 0%
  Adjustedc 1.28 (1.04, 1.55) 1.28 (1.04, 1.55) 1.00 (1.00, 1.02) 0%
Mediator: Anxiety
 >30 minutes to fall asleep
  Unadjustedb 1.36 (1.12, 1.64) 1.28 (1.05, 1.54) 1.06 (1.03, 1.11) 19%
  Adjustedd 1.26 (1.03, 1.52) 1.22 (0.99, 1.48) 1.04 (1.01, 1.08) 17%
 Difficulty falling back to sleep
  Unadjustedb 1.36 (1.13, 1.64) 1.28 (1.05, 1.56) 1.06 (1.03, 1.12) 19%
  Adjustedd 1.30 (1.07, 1.58) 1.25 (1.03, 1.51) 1.04 (1.01, 1.08) 15%

aCalculated as the natural logarithm of the indirect effect divided by the natural logarithm of the total effect.

bIncludes adjustment for survey weights.

cAdjusted for the following baseline variables: age, race, education, sex, use of mobility device, marital status, cardiovascular disease, diabetes, and survey weights.

dAdjusted for the following baseline variables: age, race, education, sex, use of mobility device, marital status, cardiovascular disease, and survey weights.