Table 2.
Genes differing by Oprm1 genotype
Region | Gene | Direction of change | Ratioa | Nominal p val. | Corrected p val.b |
---|---|---|---|---|---|
Caudoputamen | |||||
Oprm1 | ↓ | 0.88 | 0.02 | 0.26 | |
Pdyn | ↓ | 0.82 | 0.01 | 0.26 | |
N. accumbens | |||||
Gal | ↓ | 0.46 | 0.03 | 0.60 | |
Hypothalamus | |||||
Oprk1 | ↓ | 0.85 | 0.04 | 0.16 | |
Pdyn | ↓ | 0.82 | 0.03 | 0.16 | |
Penk | ↓ | 0.80 | 0.03 | 0.16 | |
Avp | ↓ | 0.60 | 0.0002 | 0.004* | |
Gal | ↓ | 0.76 | 0.002 | 0.03* | |
Oxt | ↓ | 0.68 | 0.008 | 0.07 | |
Hippocampus | |||||
Oprl1 | ↓ | 0.72 | 0.002 | 0.03* | |
Cnr1 | ↓ | 0.70 | 0.001 | 0.03* | |
Fkbp5 | ↓ | 0.82 | 0.04 | 0.23 | |
Oxtr | ↓ | 0.66 | 0.049 | 0.23 | |
Amygdala | – | – | – | – | – |
aGG vs AA (prototype)
bFalse discovery rate (5%)
*Remains significant after adjustment for multiple testing (FDR = 5%)