Fig. 2.

Forest plot of odds ratios for death at day 90 after multivariate logistic regression in patients with acute respiratory distress syndrome (n = 700). *A risk score was calculated as a composite of available severity scores (SOFA, APACHE II, APACHE III) combined using an average z score. Study effect was taken into account as a random effect covariate. Plasma levels of sRAGE (in pg.ml⁻¹), PaO₂/FiO₂, tidal volume, and PEEP are natural log-transformed in the model to meet the assumption of linearity with log odds of outcome; the ORs presented here are for each log increase in the level of plasma sRAGE, PaO₂/FiO₂, tidal volume, and PEEP. APACHE II Acute Physiology and Chronic Health Evaluation II Score, APACHE III Acute Physiology and Chronic Health Evaluation III Score, SOFA Sequential Organ Failure Assessment Score, ΔP driving pressure, PEEP positive end-expiratory pressure, sRAGE soluble receptor for advanced glycation end-products