Table 1.

Overview of potential clinical indications for cardiac PET/MRI

Potential	Indication	Comment
Strong	Cardiac inflammation	Detection and assessment of activity not satisfactory using CMR; complementary information using CMR and PET; high number of clinical cases
Strong	Ischemic heart disease	Established criteria for clinical outcome after revascularisation not satisfactory; integration of structural alterations and perfusion using PET/MRI seems plausible; high number of clinical cases with large combined morbidity and mortality; to date highly speculative due to missing data, particularly on the combination with MR coronary angiography.
Strong	Ischemic cardiomyopathy	Limited evidence available for combined PET/MRI, but generally great potential by assessing perfusion, metabolism, viability and function simultaneously. Strong potential for tissue characterization by using novel radiopharmaceuticals.
Intermediate	Acute coronary syndromes	Assessment of myocardial salvage and cardiac remodelling could guide the development of novel therapies; maybe limited relevance outside research or clinical studies
Weak	Cardiac tumours	CMR or PET(/CT) probably sufficient in most cases; anticipated added value of PET/MRI for planning of complex surgery/radiation or identification of relapse in malignant tumours