Fig. 3.

Olfactory input to the hippocampus was significantly decreased in the 5XFAD mice compared to the wild-type littermate mice. a Diagram of the coronal mouse brain sections illustrating the location of the OB at bregma + 4.28 mm. b Representative figures showing DiI-positive somata in the main OB (MOB). DiI-positive signals are mainly observed in the mitral layer of the OB. c Quantification of the DiI-positive area in the MOB. Scale bar = 50 μm. The values are given as mean ± standard error of the mean. ^***p < 0.001 indicates significant differences between the groups. OB, olfactory bulb; gr, granule layer; ipl, inner plexiform layer; mi, mitral layer; opl, outer plexiform layer; gl, glomerular layer