Fig. 4.

Medial septal inputs to the hippocampus were significantly decreased in the 5XFAD mice compared to their littermate controls. a Diagram of a mouse brain atlas illustrating the location of the MS at Bregma + 0.74 mm. b Representative figures of DiI-containing somata in the MS complex. DiI-positive cells are mainly observed in the MS nucleus. Scale bar = 200 μm. c Magnification of the white rectangles in b. d Quantification of the DiI-positive area in the MS nucleus. Scale bar = 50 μm. ^***p < 0.001 indicates significant differences between the groups. MS, medial septal nucleus; LSV, lateral septal nucleus, ventral part