Fig. 8.

The LC-hippocampal pathways were dramatically decreased in the 5XFAD mice compared with the wild-type mice. a Diagram of a mouse brain atlas illustrating the location of the LC at bregma − 5.68 mm. b Representative figures of DiI-positive somata in the pons. DiI-positive cells were mainly observed in the LC. Scale bar = 200 um. c Quantification of the DiI-positive area in the LC. Scale bar = 50 μm. ^***p < 0.001 indicates significant differences between the groups. LC, locus coeruleus; 4V, fourth ventricle