Fig. 5.

Physiological difference between zebrin-identified cerebellar modules. a Schematic drawing of unfolded cerebellar surface, adapted from [66–69], depicting post-mortem immunohistochemically determined recording locations of PC, with color-coded simple spike firing rate. Note the higher firing rate in ZII− PCs and the consistent presence of the difference, even in nearby pairs. b Summary of (a) demonstrating the significant difference in average simple spike firing rate between ZII+ and ZII− PCs, recorded in vivo. c Complex spike firing rates show a similar difference, with higher firing rates in ZII- than in ZII+ PCs. d Pharmacological block of TRPC3 with two difference blockers, genestein, and pyr3, selectively affects PC simple spike activity in ZII− PCs, indicating the contribution of TRPC3 to creating this difference