Table 1.
Patient characteristics
| Curcumin DLs | Other | DL 1 | DL 2 | DL 3 | DL 4 | DL 5 | DL 6 | DL 6a | All |
| (mg/m2) | 120 | 100 | 120 | 150 | 190 | 240 | 300 | 300 | – |
| Duration of infusion | |||||||||
| (h) | 24 | 8 | 8 | 8 | 8 | 8 | 8 | 6 | – |
| Number of patients | |||||||||
| n | 1 | 4 | 7 | 4 | 3 | 3 | 4 | 6 | 32 |
| Gender | |||||||||
| Male | |||||||||
| n (%) | 1 | 4 (100) | 5 (71) | 2 (50) | 1 (33) | 2 (67) | 4 (100) | 4 (67) | 23 (72) |
| Female | |||||||||
| n (%) | 0 | 0 (0) | 2 (29) | 2 (50) | 2 (67) | 1 (33) | 0 (0) | 2 (33) | 9 (28) |
| Age (years) | |||||||||
| Median | 65.2 | 63.7 | 58.2 | 72.8 | 61.8 | 60.6 | 67.0 | 60.3 | 62.7 |
| Range | 65.2 | 50.4–68.9 | 42.6–69.8 | 66.7–84.5 | 48.2–62.2 | 58.6–69.4 | 57.0–76.9 | 48.0–72.9 | 42.6–84.5 |
| Number of previous treatment regimes | |||||||||
| 2 | |||||||||
| n | 1 | – | – | – | – | – | – | – | 1 |
| 3 | |||||||||
| n | – | – | 1 | 1 | 1 | – | – | – | 3 |
| 4 | |||||||||
| n | – | 2 | 1 | 4 | – | 1 | 1 | 1 | 10 |
| 5 | |||||||||
| n | – | 1 | 5 | 5 | – | – | 2 | 1 | 14 |
| 6 | |||||||||
| n | – | 1 | 2 | – | 1 | – | – | – | 4 |
| 7 | |||||||||
| n | – | – | 1 | – | – | – | 1 | 1 | 3 |
| 8 | |||||||||
| n | – | – | – | – | 1 | 1 | – | 2 | 4 |
| 9 | |||||||||
| n | – | – | – | – | – | – | – | 1 | 1 |
| 10 | |||||||||
| n | – | – | – | – | – | 1 | – | – | 1 |
| ECOG score | |||||||||
| 0 | |||||||||
| n | 1 | – | 2 | 1 | 1 | 1 | – | 3 | 9 |
| 1 | |||||||||
| n | – | 4 | 3 | 3 | 1 | 1 | 2 | 2 | 16 |
| 2 | |||||||||
| n | – | – | 2 | – | 1 | 1 | 2 | 1 | 7 |
| Mean treatment duration | |||||||||
| (days) | 15 | 31 | 33.3 | 27.5 | 38.3 | 38.3 | 26.8 | 54.2 | 35.8 |