Table 3.
PK parameters for curcumin
| Patient | C max (ng/mL) | T max (h) | AUC0−Tlast (ng h/mL) | C last (ng/mL) | T last (h) |
|---|---|---|---|---|---|
| DL 3: 150 mg/m2, 8 h infusion | |||||
| 17 | 66.1 | 6.0 | 270 | 66.1 | 6.0 |
| DL 4: 190 mg/m2, 8 h infusion | |||||
| 18 | 54.7 | 2.0 | 231 | 26.4 | 6.0 |
| 19a | 3885.1 | 6.0 | 13,752 | 251.2 | 8.8 |
| 20 | 64.1 | 6.0 | 254 | 64.1 | 6.0 |
| Mean | 59.4 | 4.0 | 243 | 45.3 | 6.0 |
| SD | 6.7 | 2.8 | 16 | 26.7 | 0 |
| SE | 4.7 | 2.0 | 12 | 18.8 | 0 |
| %CV | 11 | 71 | 7 | 59 | 0 |
| DL 5: 240 mg/m2 8 h infusion | |||||
| 22 | 824.2 | 4.0 | 3077 | 61.9 | 8.5 |
| 23 | 469.4 | 2.0 | 2325 | 310.4 | 6.7 |
| Mean | 646.8 | 3.0 | 2701 | 186.2 | 7.6 |
| SD | 250.9 | 1.4 | 532 | 175.7 | 1.3 |
| SE | 171.4 | 1.0 | 376 | 124.3 | 0.9 |
| %CV | 39 | 48 | 20 | 94 | 17 |
| DL 6: 300 mg/m2, 8 h infusion | |||||
| 24 | 3484.4 | 2.0 | 17,351 | 12.9 | 7.8 |
| 25 | 1212.3 | 4.0 | 5174 | 319.1 | 8.0 |
| 26 | 1051.4 | 4.0 | 4374 | 807.1 | 6.0 |
| 27 | 815.8 | 4.3 | 3674 | 11.3 | 8.9 |
| Mean | 1641 | 3.6 | 7643 | 287.6 | 7.7 |
| SD | 1239.7 | 1.1 | 6501 | 375.4 | 1.2 |
| SE | 715.7 | 0.6 | 3753 | 216.7 | 0.7 |
| %CV | 76 | 30 | 85 | 131 | 16 |
| DL 6a: 300 mg/m2, 6 h infusion | |||||
| 28 | 2351.2 | 4.0 | 9701 | 10.4 | 6.5 |
| 29 | 1261.8 | 5.8 | 5780 | 24.9 | 6.4 |
| 30 | 1672.7 | 2.0 | 6915 | 286.2 | 6.4 |
| 31 | 1367.6 | 4.0 | 6669 | 10.6 | 6.2 |
| 32 | 767.2 | 5.9 | 2448 | 13.8 | 6.4 |
| 33 | 1147.7 | 4.0 | 5168 | 790.2 | 5.8 |
| Mean | 1428 | 4.3 | 6113 | 189.4 | 6.3 |
| SD | 540.1 | 1.4 | 2378 | 313.8 | 0.2 |
| SE | 220.5 | 0.6 | 971 | 128.1 | 0.1 |
| %CV | 38 | 34 | 39 | 166 | 4 |
aData for Patient #19 were not included in the calculation of the mean, SD, SE and %CV