Table 4.
PK parameters for THC
| Patient | C max (ng/mL) | T max (h) | AUC0−Tlast (ng h/mL) | C last (ng/mL) | T last (h) | AUC0−Tlast THC/AUC0−Tlast curcumin |
|---|---|---|---|---|---|---|
| DL 3: 150 mg/m2, 8 h infusion | ||||||
| 17 | 16.1 | 4 | 59 | 10.3 | 6.0 | 0.218 |
| DL 4: 190 mg/m2, 8 h infusion | ||||||
| 18 | 7.7 | 4.0 | 22 | 7.7 | 4.0 | 0.096 |
| 19a | 396.1 | 8.1 | 1656 | 11.8 | 8.8 | 0.122 |
| 20 | 6.6 | 6.0 | 31 | 6.6 | 6.0 | 0.121 |
| Mean | 7.2 | 5.0 | 27 | 7.2 | 5.0 | 0.109 |
| SD | 0.7 | 1.4 | 6 | 0.7 | 1.4 | 0.018 |
| SE | 0.5 | 1.0 | 4 | 0.5 | 1.0 | 0.012 |
| %CV | 10 | 28 | 23 | 10 | 28 | 16 |
| DL 5: 240 mg/m2 8 h infusion | ||||||
| 22 | 24.3 | 2.0 | 102 | 14.3 | 6.0 | 0.033 |
| 23 | 63.3 | 2.0 | 271 | 28.2 | 6.7 | 0.116 |
| Mean | 43.8 | 2.0 | 186 | 21.2 | 6.4 | 0.075 |
| SD | 27.6 | 0 | 119 | 9.9 | 0.5 | 0.059 |
| SE | 19.5 | 0 | 84 | 7.8 | 0.3 | 0.042 |
| %CV | 63 | 0 | 64 | 47 | 7 | 79 |
| DL 6: 300 mg/m2, 8 h infusion | ||||||
| 24 | 108.3 | 2.0 | 359 | 48.2 | 6.0 | 0.021 |
| 25 | 75.2 | 3.8 | 407 | 28.6 | 7.6 | 0.079 |
| 26 | 75.6 | 2.0 | 426 | 5.3 | 8.5 | 0.097 |
| 27 | 38.5 | 2.3 | 187 | 5.1 | 8.6 | 0.051 |
| Mean | 74.4 | 2.5 | 344 | 21.8 | 7.7 | 0.062 |
| SD | 28.5 | 0.8 | 109 | 20.8 | 1.2 | 0.033 |
| SE | 16.5 | 0.5 | 63 | 12.0 | 0.7 | 0.019 |
| %CV | 38 | 34 | 32 | 95 | 16 | 54 |
| DL 6a: 300 mg/m2, 6 h infusion | ||||||
| 28 | 110.4 | 2.0 | 497 | 6.9 | 6.8 | 0.051 |
| 29 | 35.1 | 4.0 | 155 | 5.2 | 6.8 | 0.027 |
| 30 | 80.1 | 2.0 | 385 | 5.2 | 7.3 | 0.056 |
| 31 | 67.6 | 2.5 | 332 | 6.0 | 6.0 | 0.050 |
| 32 | 70.7 | 5.9 | 321 | 8.4 | 6.6 | 0.131 |
| 33 | 58.3 | 5.8 | 264 | 5.7 | 6.2 | 0.051 |
| Mean | 70.3 | 3.7 | 326 | 6.2 | 6.6 | 0.061 |
| SD | 24.9 | 1.8 | 115 | 1.2 | 0.5 | 0.036 |
| SE | 10.2 | 0.7 | 47 | 0.5 | 0.2 | 0.015 |
| %CV | 35 | 49 | 35 | 20 | 7 | 59 |
aData for Patient #19 were not included in the calculation of the mean, SD, SE and %CV