Table 1.
Survey on experiments
| # | Experiment | Sampling time | Pigs | Arteries | Premounted stents on balloons | Measurements (n) | Results, Table nos. |
|---|---|---|---|---|---|---|---|
| 1 | Loss during passage through valve, sheath, and blood (in vitro) | Immediately after passage of valve, catheter, and floating in blood | 0 | 0 | No | PTA catheters = 3 PTCA catheters = 4 |
2 |
| 2 | Drug and additive content during PTA at treatment site | During balloon inflation | n = 4 | External iliac, n = 4 | No | Inflated balloon + artery in situ | 2 |
| 3 | Drug and additive following PTA in arterial wall | Arteries: 10–30 min after balloon deflation and retraction | n = 4 | External iliac, n = 8 | No | Paclitaxel and resveratrol in the arterial wall and on balloons after inflation, deflation, and retraction | 2 |
| 4 | Drug and additive content following PTCA | Arteries: 10–30 min after balloon deflation and retraction | n = 4* | Coronary, right, left anterior descending, left circumflex; n = 8 arteries | No | Paclitaxel and resveratrol in the arterial wall and on balloons after inflation, deflation and retraction | 2 |
| 5 | MALDI Matrix-assisted laser desorption/ionization | Internal iliac arteries | n = 6 | Internal iliac, n = 12 (only 1 example shown) | No | Paclitaxel displayed in histological slices | Figure 2 |
| 6 | Impact of paclitaxel-resveratrol-coated balloon catheters on neointimal proliferation | 4 weeks after treatment | 2 treatment arms, n = 6/arm | External iliac/femoral, 2 treatment arms, n = 12/arm | Yes | Tolerance, QCA, histomorphometry | 3 |
| 7 | Impact of paclitaxel-resveratrol-coated balloon catheters on neointimal proliferation and ejection fraction, downstream myocardium | 4 weeks after treatment | 3 treatment arms, n = 5/arm | Coronary arteries, left anterior descending, left circumflex, 3 treatment arms, n = 9–10/arm; 5 hearts/arm | Yes, in high-dose group: only 1st balloon per treatment site | Effects including ejection fraction, QCA, histomorphometry of coronary arteries, histology of myocardial tissue | 3, 4, 5 |
| 8 | Impact of resveratrol-only-coated balloon catheters on neointimal proliferation | 4 weeks after treatment | 2 treatment arms, n = 7/arm | External iliac/femoral, 2 treatment arms, n = 7/arm | Yes | Tolerance, QCA, histomorphometry | 3 |
| 9 | Impact of resveratrol-only coating on neointimal proliferation | 4 weeks after treatment | 2 treatment arms, n = 8/arm** | Coronary arteries, right, left anterior descending, left circumflex; 11–12 arteries/arm | Yes | Tolerance, QCA, histomorphometry | 3 |
| 10 | Impact of resveratrol-only coating on early healing | 3 or 7 days after treatment, data combined because of no recognizable difference | 2 treatment arms, n = 8 (total) | External iliac/femoral, 2 treatment arms, n = 8/arm | No | Histology | 6 |
*Same animals as in line 3; **including pigs of line 8