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. 2018 Jun 19;53(9):1065–1078. doi: 10.1007/s00535-018-1486-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Time to leukopenia and the doses of AZA according to the genotype of NUDT15 codon 139. a Time to leukopenia after starting treatment with thiopurines is plotted in terms of the genotype. Average time to leukopenia in patients with the Cys/Cys and Arg/Cys genotypes was significantly shorter than that for those with the Arg/Arg genotype. b Doses of thiopurines at the time when severe leukopenia was diagnosed were plotted. The 6-MP dose was adjusted to AZA equivalents by multiplying by 2.08. The dose of the patients carrying the p.Arg139Cys allele was significantly lower than that of the patients with Arg/Arg. *p < 0.05, **p < 0.005