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. 2018 Jun 19;53(9):1065–1078. doi: 10.1007/s00535-018-1486-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Manhattan plots for results of the discovery and conditional GWASs for thiopurine-induced leukopenia and alopecia in Japanese individuals. Single-nucleotide polymorphisms are plotted according to chromosomal location, with the − log₁₀(P) from the results of GWASs. The red line indicates the threshold for genome-wide significance (p = 1E−8). The blue line indicates the threshold for nominal significance (p = 1E−6). a GWAS for thiopurine-induced leukopenia, b conditional GWAS for leukopenia on rs116855232 (p.Arg139Cys), c GWAS for alopecia, and d conditional GWAS for alopecia on rs116855232. All significant associations disappeared in the conditional GWASs