Table 2.
Associations between genotype of codon 139 and severe adverse events associated with thiopurines
| Genotype | N | All AEs | Acute severe leukopenia (WBC < 2000/μL, < 8 weeks) | Severe alopecia | ||||
|---|---|---|---|---|---|---|---|---|
| Frequencies (%) | Frequencies (%) | p value* | OR (95% CI) | Frequencies (%) | p value* | OR (95% CI) | ||
| Arg/Arg (RR) | 958 | 258 (26.9%) | 3 (0.3%) | (reference) | 1.0 | 1 (0.1%) | (reference) | 1.0 |
| Arg/His (RH) | 7 | 2 (28.6%) | 0 (0%) | 9.90E−01 | – | 0 (0%) | 9.94E−01 | – |
| Arg/Cys (RC) | 275 | 135 (49.1%) | 11 (4.0%) | 7.43E−05 | 13.4 (3.7–48.4) | 3 (1.1%) | 4.16E−02 | 10.6 (1.1–101) |
| Cys/His (CH) | 2 | 2 (100.0%) | 1 (50.0%) | 1.62E−04 | 318 (15.9–6352) | 0 (0%) | 9.97E−01 | – |
| Cys/Cys (CC) | 49 | 49 (100.0%) | 33 (67.3%) | 7.30E−24 | 807 (219–2969) | 44 (89.8%) | 3.07E−16 | 8421 (963–73625) |
CI confidence interval
*Logistic regression test