Table 3.
Frequencies of adverse events by diplotype of NUDT15 and linear correlation to enzyme activity
| Diplotype | Estimated enzyme activity | Frequencies (2KJPN) | Frequencies (MENDEL) | Leukopenia (WBC < 3000/μL) | Severe leukopenia (WBC < 2000/μL) | Acute severe leukopenia (WBC < 2000/μL, < 8 weeks) | Severe alopecia |
|---|---|---|---|---|---|---|---|
| *1*1 | NN | 1615 (79.3%) | 697 (71.9%) | 71 (10.2%) | 12 (1.7%) | 3 (0.4%) | 0 (0.0%) |
| *1*2 | NL | 111 (5.5%) | 79 (8.1%) | 31 (39.2%) | 8 (10.1%) | 1 (1.3%) | 1 (1.3%) |
| *1*3 | NL | 248 (12.2%) | 125 (12.9%) | 31 (24.8%) | 16 (12.8%) | 9 (7.2%) | 2 (1.6%) |
| *1*4 | NI | 1 (0.049%) | 7 (0.72%) | 1 (14.3%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| *1*5 | NI | 30 (1.5%) | 17 (1.8%) | 4 (23.5%) | 1 (5.9%) | 0 (0.0%) | 0 (0.0%) |
| *1*6 | NI | 4 (0.20%) | 4 (0.41%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| *1*9 | NL | 0 (0.0%) | 1 (0.10%) | 1 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| *1*10 | – | 1 (0.049%) | 0 (0.0%) | – | – | – | – |
| *2*2 | LL | 3 (0.15%) | 2 (0.21%) | 2 (100.0%) | 2 (100.0%) | 2 (100.0%) | 2 (100.0%) |
| *2*3 | LL | 7 (0.34%) | 16 (1.6%) | 16 (100.0%) | 15 (93.8%) | 14 (93.3%) | 16 (100.0%) |
| *2*4 | IL | 0 (0.0%) | 1 (0.10%) | 1 (100.0%) | 1 (100.0%) | 1 (100.0%) | 0 (0.0%) |
| *2*5 | IL | 0 (0.0%) | 1 (0.10%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| *2*9 | LL | 1 (0.049%) | 0 (0.0%) | – | – | – | – |
| *2*11 | – | 1 (0.049%) | 0 (0.0%) | – | – | – | – |
| *3*3 | LL | 12 (0.59%) | 17 (1.8%) | 15 (88.2%) | 11 (64.7%) | 9 (60.0%) | 16 (94.1%) |
| *3*4 | IL | 0 (0.0%) | 1 (0.10%) | 1 (100.0%) | 1 (100.0%) | 0 (0.0%) | 0 (0.0%) |
| *3*5 | IL | 1 (0.049%) | 2 (0.21%) | 1 (50.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| *5*5 | II | 1 (0.049%) | 0 (0.0%) | – | – | – | – |
| NN | 697 (71.86%) | 71 (10.2%) | 12 (1.7%) | 3 (0.4%) | 0 (0.0%) | ||
| NI | 28 (2.89%) | 5 (17.9%) | 1 (3.6%) | 0 (0.0%) | 0 (0.0%) | ||
| NL | 205 (21.13%) | 63 (30.7%) | 24 (11.7%) | 10 (4.9%) | 3 (1.5%) | ||
| IL | 5 (0.52%) | 3 (60.0%) | 2 (40.0%) | 1 (20.0%) | 0 (0.0%) | ||
| LL | 35 (3.61%) | 33 (94.3%) | 28 (80.0%) | 25 (71.4%) | 34 (97.1%) | ||
| Correlation analysis | r 2 | 0.926 | 0.847 | 0.718 | 0.504 | ||
| p value | 0.0087 | 0.027 | 0.07 | 0.18 | |||
Bold numbers indicate the significant correlations (p-values < 0.05)
NN normal and normal (1*1), NI normal and intermediate (*1*4, *1*5, *1*6), NL normal and low (*1*2, *1*3, *1*9), IL intermediate and low (*2*4, *2*5, *3*4, *3*5), LL low and low (*2*2, *2*3, *3*3)