Table 4.

Comparison of logistic regression models to predict thiopurine-induced leukopenia and severe alopecia

Phenotype	Leukopenia (WBC < 3000/μL)		Severe leukopenia (WBC < 2000/μL)		Acute severe leukopenia		Severe alopecia
Model	AUC (95%CI)	p value*	AUC (95 %CI)	p value*	AUC (95%CI)	p value*	AUC (95%CI)	p value*
NUDT15_codon139	0.706 (0.665–0.748)	NA	0.841 (0.786–0.896)	NA	0.921 (0.869–0.972)	NA	0.991 (0.981–1.000)	NA
NUDT15_haplotype	0.722 (0.680–0.764)	0.013	0.843 (0.789–0.898)	0.706	0.916 (0.864–0.967)	0.168	0.990 (0.979–1.000)	0.972
NUDT15_codon139 + ABCC4	0.724 (0.681–0.767)	0.555	0.839 (0.777–0.901)	0.966	0.924 (0.871–0.978)	0.925
NUDT15_codon139 + RUNX1	0.735 (0.691–0.779)	0.358	0.858 (0.804–0.912)	0.665	0.927 (0.876–0.979)	0.858
NUDT15_codon139 + ABCC4 + RUNX1	0.744 (0.701–0.787)	0.217	0.856 (0.798–0.913)	0.718	0.931 (0.879–0.983)	0.790
NUDT15_haplotype + ABCC4	0.736 (0.693–0.780)	0.327	0.844 (0.783–0.904)	0.949	0.923 (0.870–0.976)	0.963
NUDT15_haplotype + RUNX1	0.746 (0.702–0.790)	0.194	0.861 (0.807–0.914)	0.615	0.927 (0.876–0.978)	0.870
NUDT15_haplotype + ABCC4 + RUNX1	0.753 (0.710–0.796)	0.127	0.859 (0.803–0.915)	0.645	0.931 (0.881–0.982)	0.775

Bold number indicate the significant correlations (p-value < 0.05)

*p values for comparison with AUC of NUDT15_codon139