Figure 8.

EGFR activation-mediated EMT is correlated with PD-L1 induction in human cancer simples.

(A) HE and IHC staining of E-cadherin, Vimentin, PD-L1, p-EGFR and p-STAT3 from a patient diagnosed as primary mandibular adenoid cystic carcinoma.(B) The panoramic radiography and Maxillofacial CT of the mandibular adenoid cystic carcinoma patient.(C) OncoPrint of EGF-EGFR-CD274 pathway alterations and survival analysis in head and neck cancer. Genomic alterations of different members in this pathway are mutually exclusive. Patients with EGF-EGFR-CD274 pathway alteration have worse overall survival and disease-free survival than cases without an alteration. Case with alteration(s) means patient with genetic alteration of either EGF, EGFR or CD274 and case without alteration(s) means patient has none genetic alteration of either EGF, EGFR or CD274.