Figure 1.

Schematic representation of the in vivo experiments conducted. Specifically, ChREBP wild-type (ChREBPWT) and knockout (ChREBPKO) mice were transfected with a myristoylated/activated form of AKT1 (myr-AKT1), either alone (a) or in association with c-Met (b) or an oncogenic form of NRas (NRasV12; c), via hydrodynamic gene delivery. ChREBPWT were also injected with the empty vector (control). Mouse were monitored daily by abdominal palpation and sacrificed when palpable masses were appreciable. The number of mice used for the experiments is indicated. Abbreviation: w.p.i., weeks post injection.