Figure 6.

Genetic ablation of ChREBP in the mouse liver does not affect tumor development driven by AKT/Ras co-expression. (a,b) Overexpression of AKT/Ras triggered the development of multiple hepatocellular carcinomas and cholangiocarcinomas both in ChREBP WT (AKT/Ras/ChREBP; n = 20) and ChREBP KO (AKT/Ras/ChREBPKO; n = 20) mice. Tumors in the two mouse cohorts developed with the same latency and were indistinguishable histopathologically (a,b) as well as in body weight (c), liver weight (d), and liver/body weight ratio (e). Original magnifications: 40x and 100x. Scale bar: 500µm for 40x, 100µm for 100x. Abbreviations: HE, hematoxylin and eosin staining; w.p.i, weeks post injection. Tukey–Kramer test: P < 0.0001 a, vs control (mice injected with empty vector).