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. 2018 Jul 18;17(12):1496–1512. doi: 10.1080/15384101.2018.1489182

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Figure 9. — ChREBP is overexpressed in human hepatocellular carcinoma (HCC). (a) Levels of ChREBP mRNA were significantly more elevated in HCC (n = 60) than corresponding non-tumorous surrounding livers (SL; n = 60), as detected by quantitative reverse-transcription PCR. Number target (NT) = 2−ΔCt, wherein ΔCt value of each sample was calculated by subtracting the average Ct value of the ChREBP gene from the average Ct value of the β-actin gene. Mann–Whitney test: a, vs SL, P < 0.0001. (b) Levels of ChREBP mRNA are significantly higher in HCC with poorer outcome (HCCP) than in tumors with better prognosis (HCCB). Mann–Whitney test: a, vs HCCB, P < 0.0001. (c) Kaplan–Meier survival curves of human HCC with high and low ChREBP mRNA levels, showing the unfavorable outcome of patients with high ChREBP mRNA expression.